TABLE 2.

Pathways significantly changed between infection severities (P < 0.05).

Pathway	Class	Increased in infection severity (PEDIS)
Lipoic acid metabolism	Metabolism of vitamins and cofactors	Mild
Two-component systems	Signal transduction	Mild
Bacterial invasion to epithelial cells	Bacterial infectious disease	Mild
Glycerolipid metabolism	Metabolism of lipid	Moderate
TCA cycle	Metabolism of carbohydrate	Moderate
Mismatch repair	Replication and repairing DNA	Severe