Table 1.

Cancer type impact on osteocyte topology.

Cancer type	Origin	Bone growth	Osteocyte topology	References
Osteogenic Sarcoma.	Mesenchymal cells	Mixture	Canaliculi upregulated, Lacunae empty.	Stinson, 1975
Osteoma (benign).	Unknown	Osteoblastic	Canaliculi down regulated, retarded growth.	Stinson, 1975
Myeloma	Plasma cells / White blood cells	Primarily osteolytic	Osteocyte lacunae spherical, canaliculi reduced in number, shorter, distorted.	Eisenberger et al., 2008 Kristinsson et al., 2011
Metastasis (group A)	Lung, Breast, Liver	Primarily osteolytic	Unknown	Eisenberger et al., 2008
Metastasis (group B)	Prostate	Primarily osteoblastic	Unknown	Logothetis and Lin, 2005