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. 2020 Jul 22;11:1591. doi: 10.3389/fimmu.2020.01591

Figure 2.

Figure 2

Macrophage polarization toward M1 phenotype is related to different resistance to sepsis between female and male mice. The enhanced trained immunity exhibited the increased M1 phenotype macrophage. (A) The percentage of F4/80+CD11b+ marked macrophage was significantly increased in the spleen from both E. coli and TI + E. coli groups (n = 3/group). (B) The percentage of F4/80+iNOS+ M1 macrophage was significantly increased in PBMCs from both E. coli and TI + E. coli groups (n = 3/group). (C) The percentage of F4/80+CD206+ M2 macrophage in PBMCs from both E. coli and TI + E. coli groups (n = 3/group). Data with error bars are presented as the mean± standard error (SEM). Each panel is a representative experiment of at least three independent biological replicates. *p < 0.05, **p < 0.01, and ***p < 0.001, paired Student's t-test comparing E. coli group, TI + E. coli group and control group in same gender. #p < 0.05, ##p < 0.01, paired Student's t-test comparing E. coli group and TI + E. coli group.