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. 2020 Jul 28;11:3766. doi: 10.1038/s41467-020-17556-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Levels of DPP4 activity (left panels) and protein (right panels) in a bone marrow, b jejunum, c liver, d whole ventricle, e kidney, f pancreas and g spleen from WT mice that were maintained on control diet (CD) or a high fat, fructose and cholesterol (HFFC) diet for 10 weeks and then the same diets supplemented with (+) or without (−) the DPP4 inhibitor (DPP4i) MK-0626 for 14 weeks. Data shown are mean ± SEM. For a, n = 5 mice per group. For b–g, n = 9 or 10 mice per group, except where n = 8 as indicated on the graph above the data set. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. DPP4i-treated. ^##P < 0.01, ^####P < 0.0001 for CD vs. HFFC. Data were analysed by two-way ANOVA. Source data are provided as a Source data file.