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. 2020 Jul 28;10:12644. doi: 10.1038/s41598-020-69267-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Role of integrins in modulating collagen organization and gene expression in an in vitro model of tendon differentiation. (a) H&E staining analysis of RGD and RGDS-induced disorganization of the ECM, which is typically oriented with the direction of stretching force. The arrow (↕) indicates the direction of stretching force. For each condition, the lower panel represents 4 × magnification of the selected region (dashed red box) in the corresponding upper panel. Scale bars = 250 μm (b) qRT-PCR analysis of regulation of gene expression in response to mechanical stimulation and treatment with RGD and RGDS. Decreasing ΔCt indicates increasing gene expression and vice-versa. Two-way ANOVA followed by Bonferroni's multiple comparison test; mean ± SE; ns P > 0.05; * P ≤ 0.05; **P ≤ 0.01; n = 3 biological replicates.