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. 2020 Jul 28;10:12636. doi: 10.1038/s41598-020-69533-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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B. clausii and its supernatant significantly counteract the Rotavirus-induced alteration in MUC-5, ZO-1 and Occludin expression in human enterocytes. Rotavirus (RV) (10 pfu/cell) significantly reduced the expression of MUC5AC (A), ZO-1 (B) and Occludin (C) in human enterocytes, whereas both B. clausii probiotic strains (3 × 10⁸ cells/mL) and B. clausii supernatant (Sup, dilution 1:100) significantly increased the expression of these proteins in basal condition and blunted the RV effect. *p < 0.05 vs NT; ^#p < 0.05 vs RV.