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. 2020 Jul 22;11:1441. doi: 10.3389/fmicb.2020.01441

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Copyright © 2020 Zhang, Zhao, Chen, Teng, Jiang, Feng, Li, Yuan, Xu, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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H7N9-derived HA was not able to enhance the pathogenicity and replication of H9N2 virus in mouse. Mice were intranasally inoculated with a single dose of 10⁶ EID₅₀ of either the parental H9N2 CK/F98 virus or the CK/F98-4664HA hybrid virus with HA gene being replaced by its counterpart from H7N9 SH/4664 virus. (A) Weight loss during a 14-day observation period. (B) Virus titers in animal lungs, as determined by EID50 using MDCK cells. (C) Virus titers in animal nasal turbinates, as determined by EID50 using MDCK cells. n = 3 for each group. Data are expressed as mean ± SEM. *P < 0.05 by one-way ANOVA.