Table 3.
Characteristics and outcomes of women with a new pregnancy after CIUE.
| Characteristic | Recurrent CIUE N = 11 | No recurrent CIUE N = 9 | p value* |
|---|---|---|---|
| Ethnic group†—no | > 0.99 | ||
| Caucasian | 9 | 8 | |
| North African | 2 | 1 | |
| Addiction—no. (%) | > 0.99 | ||
| Tobacco | 6 | 4 | |
| Cannabis | – | – | |
| Pregnancies characteristics | N = 27 | N = 10 | p value |
| Age—y | 0.003 | ||
| Median | 34 | 28 | |
| Interquartile range | 33–39 | 23–33 | |
| Age ≥ 35 y—no. (%) | 13 (48.1) | 2 (20.0) | |
| BMI at first trimester† | 0.02 | ||
| Median | 23.8 | 22.6 | |
| Interquartile range | 22.4–25.6 | 19.8–25.2 | |
| BMI ≥ 30—no. (%) | 1 (3.7) | – | |
| Pregnancies ≥ 22 WGA—no./total no. (%) | 11 (40.7) | 9 (90.0) | 0.01 |
| Gestational diabetes | 1/11 (9.1) | – | > 0.99 |
| Preeclampsia | – | – | |
| Premature delivery threat | – | 1/9 (11.1) | > 0.99 |
| Premature rupture of membranes | – | 1/9 (11.1) | > 0.99 |
| Prenatal hospitalization | 8/11 (72.7) | 4/9 (44.4) | 0.10 |
| Obstetrical outcomes | |||
| Miscarriage—no. (%) | 14 (51.9) | 1 (10.0) | 0.03 |
| Stillbirth—no. (%) | 1 (3.7) | 1 (10.0) | 0.47 |
| Week of gestation | 35 | 36 | |
| FGR | < 3th Percentile | No | |
| TOP—no. (%) | 4 (14.8) | 0 (0.0) | 0.56 |
| Week of gestation—mean | 23 | – | |
| FGR < 3rd percentile—no./total no | 3/4 | – | |
| Live birth—no. (%) | 8 (29.6) | 8 (80.0) | 0.01 |
| FGR—no./total no. (%) | 2/7 (28.6) £ | 1/8 (12.5) | 0.57 |
| < 3rd percentile | 2/7 (28.6) £ | – | |
| Prematurity—no./total no. (%) | 3/8 (37.5) | 1/8 (12.5) | 0.57 |
| [28–31+6 WGA] | 2 | – | |
| [32–33+6 WGA] | 1 | – | |
| [34–36+6 WGA] | – | 1 | |
| Neonatal death no./total no. (%) | – | – | |
| Live birth without comorbidity | 4/8 (50.0) | 6/8 (75.0) | 0.61 |
| Pathology issue | |||
| CIUE | 20 | – | |
| No CIUE | 1 | 10 | |
| Unknown | 6 | 0 | |
CIUE chronic intervillositis of unknown etiology, BMI body mass index, WGA weeks gestational age, FGR fetal growth restriction, TOP termination of pregnancy.
*The non-parametric Mann–Whitney test was used to perform univariate analyses of quantitative variables, and Fisher’s exact test was used for univariate analyses of qualitative variables.
†BMI is the weight in kilograms divided by the square of the height in meters.
£Weight data were missing for one live birth.