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. 2020 Jul 28;10:12655. doi: 10.1038/s41598-020-69543-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed proteins in common for MO3.13 cells treated with haloperidol, clozapine and clozapine + d-serine (a). The UPS-related proteins modulated by those treatments are show in (b). Haloperidol and Clozapine also modulated proteins related to eIF2 signaling (c) and to the actin cytoskeleton (d). Proteins in shades of red are upregulated, while the ones in shades of blue are downregulated. This figure was made using Rstudio (version 1.2.5033)¹²³, R (version 3.6.2)¹²⁴, Pheatmap package (version 1.0.12)¹²⁵.