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. 2020 Jul 22;11:1118. doi: 10.3389/fphar.2020.01118

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Copyright © 2020 Yao, Sun, Wei, Zhang, Chen and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of Kae on the Nrf2/HO-1 signaling pathway. (A, B) The effect of Kae on the levels of Nrf2 and HO-1 in HUVECs. (C, D) The effect of Kae and 100 μmol/l H₂O₂ on the levels of Nrf2 and HO-1 in HUVECs. (E, F) The effect of Kae and paraquat on the levels of Nrf2 and HO-1 in mice. Data are expressed as the mean ± standard deviation of three independent experiments. *P < 0.05 and **P < 0.01, compared with the control group. ^#P < 0.05 and ^##P < 0.01, compared with the model group.