Table 2.
Detection performance of multiple tumor-associated autoantibodies determined by ELISA.
| Panel no. | AUC value (95% CI) | Adjusted AUC value (95% CI) | SE (%) | SP (%) | ||||
|---|---|---|---|---|---|---|---|---|
| CRC | AA | CRC | AA | CRC | AA | CRC | AA | |
| 1 | 0.75 (0.69–0.81) | 0.74 (0.67–0.82) | 0.75 (0.68–0.81) | 0.74 (0.66–0.82) | 61.24 | 74.32 | 18.12 | 64.55 |
| 2 | 0.72 (0.66–0.79) | 0.75 (0.68–0.83) | 0.72 (0.63–0.79) | 0.76 (0.67–0.85) | 55.04 | 75.68 | 84.55 | 63.64 |
| 3 | 0.74 (0.67–0.80) | 0.63 (0.55–0.71) | 0.74 (0.66–0.80) | 0.67 (0.57–0.77) | 65.89 | 79.73 | 72.73 | 50.00 |
| 4 | 0.76 (0.70–0.82) | 0.75 (0.68–0.83) | 0.76 (0.68–0.83) | 0.76 (0.66–0.85) | 77.52 | 75.68 | 69.09 | 64.55 |
| 5 | 0.78 (0.72–0.84) | 0.75 (0.68–0.83) | 0.79 (0.71–0.85) | 0.79 (0.69–0.87) | 75.19 | 75.68 | 70.00 | 63.64 |
ELISA, enzyme-linked immunosorbent assay; AUC, area under the curve; SE, sensitivity; SP, specificity; CI, 95% confidence interval; CRC, colorectal cancer; AA, advanced adenoma; 1, ALDH1B1+CTAG1; 2, ALDH1B1+CENPF; 3, CTAG1+CENPF; 4, ALDH1B1+CTAG1+CENPF; 5, ALDH1B1+CTAG1+CENPF+UQCRC.