TABLE 3.

Analysis of the final AS signature in stratified ESCA cohorts.

Characteristics	High risk	Low risk	HR (95% CI)	P-value
Age (years)
≤60	47	46	5.29 (2.45-11.4)	< 0.001
>60	46	46	6.74 (2.95-15.43)	< 0.001
Gender
Male	83	75	5.49 (3.14-9.60)	< 0.001
Female	11	16	7.73 (0.86-69.63)	0.068
Tumor grade
G1/2	43	49	7.53 (3.09-18.35)	< 0.001
G3	31	17	9.87 (2.32-42.09)	0.002
Pathological stage
Stage I/II	47	56	5.04 (2.21-11.50)	< 0.001
Stage III/IV	43	34	6.80 (3.28-14.09)	< 0.001
T stage
T1/2	32	40	4.18 (1.83-9.56)	< 0.001
T3/4	56	50	6.39 (3.13-13.08)	< 0.001
M stage
M0	70	75	5.57 (2.99-10.37)	< 0.001
M1	8	4	7.32 (0.88-60.59)	0.065
N stage
N0	34	42	6.63 (2.10-20.93)	0.001
N1	37	34	4.84 (2.41-9.73)	< 0.001
N2/3	18	11	5.07 (1.45-17.72)	0.011

HR, hazard ratio; CI, confidence interval.