Table 1.
Summary of papers at the junction of immunity and neurodegeneration in Drosophila.
| Gene | Immune phenotype | Neurological phenotype | References |
|---|---|---|---|
| pirk/rudra/pims (loss of function) | Overactivation of IMD | Locomotion, reduced lifespan, brain neurodegeneration | (77) |
| trabid (loss of function) | Overactivation of IMD | Locomotion, reduced lifespan, brain neurodegeneration | (77) |
| transglutaminase (loss of function) | Overactivation of IMD | Locomotion, reduced lifespan, brain neurodegeneration | (77) |
| dnr1 (loss of function) | Overactivation of IMD | Locomotion, reduced lifespan, brain neurodegeneration | (127) |
| cdk5 (loss of function) | Overactive immunity through reduction of autophagy | Loss of DA neurons | (19) |
| Toll and IMD activity increases | Overactive immunity | Age-dependent neurodegeneration in a model of pTBI | (136) |
| yorkie activity | Suppression of IMD and Toll | Reduction of PolyQ-mediated neurodegeneration | (137) |
| relish (knock-down in DA neurons) | Suppression of IMD | Increased resistance to paraquat, rescue of motility defects and DA neurons in a Drosophila model of PD | (138) |
| relish (loss of function) | Suppression of IMD | Suppression of retinal degeneration in norpA mutants | (139) |
| draper activity | Glial phagocytosis | Better clearance of Aβ-amyloid | (140) |
| draper (age-dependent reduction) | Dysfunctional glial-mediated engulfment | Neuronal death | (141) |
| spz-5 (in neurons) | Activation of Toll-6 in glia | Neuronal death; dying neurons signal to glia | (142) |
We only list those showing a causative link between immune activity or immune-related signaling and neurological phenotype.