Study	Reason for exclusion
Bongers‐Schokking 2000	This is a non‐randomised clinical controlled trial studying the timing and dose of thyroid hormone replacement on development in infants with CHT.
Bongers‐Schokking 2005	This is a non‐randomised clinical controlled trial studying the timing and dose of thyroid hormone replacement on development in infants with CHT.
Campos 1995	This is a non‐randomised clinical controlled trial studying the outcome of low dose initial thyroxine therapy for CHT.
Cassio 2003	This is a randomised controlled clinical trial of thyroxine (T4) plus triiodothyronine (T3) versus T4 alone in CH patients.
Chiesa 1994	This is a non‐randomised clinical controlled trial studying the growth of children with CHT before and during treatment.
Dubuis 1996	This is a non‐randomised clinical controlled trial studying the outcome of severe CHT using early high dose T4 therapy.
Gunn 1996	This is a non‐randomised clinical controlled trial.
Salerno 2002	This is a non‐randomised clinical controlled trial studying the effect of different starting doses of T4 on growth and outcome at four years of age in CHT.
Schwartz 1994	This is a non‐randomised clinical controlled trial studying the outcome in children with CHT treated with varying amounts of T4 during first 2 years of life. This does not fulfill the objective of the review.
Simoneau‐ Roy 2005	This is a non‐randomised clinical controlled trial.
Touati 1997	This is a non‐randomised clinical controlled trial.
Vanhole 1997	This is a randomised clinical controlled trial looking at replacement thyroxine therapy in hypothyroxinaemia of prematurity and not in congenital hypothyroidism.

CHT = congenital hypothyroidism