Table 3.

Shift of Treatment Frequency of Esketamine Nasal Spray from Week 4 to Week 8, Week 24, and Week 44 of the Optimization/Maintenance Phase

	Regimen at week 4
	Every other week	Weekly	Total
Regimen at week 8
Every other week,	189 (35.9%)	78 (14.8%)	267 (50.8%)
Weekly, and	61 (11.6%)	198 (37.6%)	259 (49.2%)
Total	250 (47.5%)	276 (52.5%)	526 (100.0%)
Regimen at week 24
Every other week,	138 (39.4%)	65 (18.6%)	203 (58.0%)
Weekly, and	41 (11.7%)	106 (30.3%)	147 (42.0%)
Total	179 (51.1%)	171 (48.9%)	350 (100.0%)
Regimen at week 44
Every other week,	71 (41.3%)	39 (22.7%)	110 (64.0%)
Weekly, and	17 (9.9%)	45 (26.2%)	62 (36.0%)
Total	88 (51.2%)	84 (48.8%)	172 (100.0%)

Note: Data presented as the number and percentage of patients within each week.