Jin 2013.

Study characteristics
Patient Sampling	Serum BDG collected twice weekly as part of a prospective study
Patient characteristics and setting	Adult patients with hematological malignancies who had been admitted to the hospital between 2005 and 2010. Of the 378 patients in the study, 143 had proven or probable invasive aspergillosis. The age range of patients was between 20 and 76 years, and most were male (78%)
Index tests	Glucatell test using 80 pg/mL as cut‐off for positivity
Target condition and reference standard(s)	Invasive aspergillosis determined by the 2002 EORTC criteria
Flow and timing	Unclear time frame between sample and reference standard; possible IA cases were excluded from the analysis
Comparative
Notes
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Yes
Could the selection of patients have introduced bias?		Low risk
Are there concerns that the included patients and setting do not match the review question?			Low concern
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
Could the reference standard, its conduct, or its interpretation have introduced bias?		Low risk
Are there concerns that the target condition as defined by the reference standard does not match the question?			Low concern
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	No
Could the patient flow have introduced bias?		High risk