Fig. 10.
Proposed mechanism of Nrf2/SIKE-mediated hepatic injury induced by long-term PM2.5exposure. After PM2.5 long-term challenge, down-regulated activation of Nrf2 repressed SIKE expression, contributing to oxidative stress and inflammatory response through reducing anti-oxidants and facilitating TBK1/NF-κB signaling. These effects led to hepatic injury consequently. However, Juglanin treatment showed protective effects against PM2.5-induced liver injury by improving Nrf2/SIKE signaling pathway.