Figure 1.

Timeline of Experiments. Rats were exposed to restraint stress (2 h/day for 10 days, PND 30–40). Then, the animals were subjected to different treatments between PND 41 and 55 of age. Following the interventions, anxiety or depression-like behaviors, BDNF levels, Oxidative stress markers and mRNA expression of BDNF and 5HT₃ receptor in prefrontal cortex were examined.

Abbreviation: PND, postnatal day; SP, Spirulina platensis; EX, voluntary exercise; EE, enriched environment; OFT, open field test; EPM, elevated plus maze; FST, force swimming test.