Trial ID	Review's primary and secondary outcomes	Timing of outcome measurement
Ensor 2015	HbA1c	2, 4, 6, 8, 10 months
	Body weight (kg)	2, 4, 6, 8, 10 months
	Adverse events	10 months
	Diabetes complications	‐
	All‐cause mortality	‐
	Health‐related quality of life	‐
	Anthropometric measures other than body weight (kg)	2, 4, 6, 8, 10 months
	Lipid profile	2, 4, 6, 8, 10 months
	Glucose levels (fasting)	2, 4, 6, 8, 10 months
	Serum insulin	2, 4, 6, 8, 10 months
	Insulin sensitivity	‐
	Socioeconomic effects	‐
Barriocanal 2008	HbA1c	3 months
	Body weight (kg)	4, 6, 8, 10 weeks and 3 months
	Adverse events	3 months
	Diabetes complications	‐
	All‐cause mortality	‐
	Health‐related quality of life	‐
	Anthropometric measures other than body weight (kg)	3 months
	Lipid profile	3 months
	Glucose levels (fasting)	3 months
	Serum insulin	3 months
	Insulin sensitivity	‐
	Socioeconomic effects	‐
Maki 2008	HbA1c	4, 8, 12, 16 weeks
	Body weight (kg)	12, 16 weeks
	Adverse events	16 weeks
	Diabetes complications	‐
	All‐cause mortality	‐
	Health‐related quality of life	‐
	Anthropometric measures other than body weight (kg)	‐
	Lipid profile	12, 16 weeks
	Glucose levels (fasting)	4, 8, 12, 16 weeks
	Serum insulin	12, 16 weeks
	Insulin sensitivity	‐
	Socioeconomic effects	‐
Grotz 2003	HbA1c	2, 4, 6, 8, 10, 12, 13, 15, 17 weeks
	Body weight (kg)	‐
	Adverse events	17 weeks
	Diabetes complications	‐
	All‐cause mortality	‐
	Health‐related quality of life	‐
	Anthropometric measures other than body weight (kg)	‐
	Lipid profile	‐
	Glucose levels (fasting)	2, 4, 6, 8, 10, 12, 13, 15, 17 weeks
	Serum insulin	‐
	Insulin sensitivity	‐
	Socioeconomic effects	‐
Colagiuri 1989	HbA1c	6 weeks
	Body weight (kg)	6 weeks
	Adverse events	‐
	Diabetes complications	‐
	All‐cause mortality	‐
	Health‐related quality of life	‐
	Anthropometric measures other than body weight (kg)	‐
	Lipid profile	6 weeks
	Glucose levels (fasting)	6 weeks
	Serum insulin	‐
	Insulin sensitivity	‐
	Socioeconomic effects	‐
Cooper 1988	HbA1c	6 weeks
	Body weight (kg)	6 weeks
	Adverse events	‐
	Diabetes complications	‐
	All‐cause mortality	‐
	Health‐related quality of life	‐
	Anthropometric measures other than body weight (kg)	‐
	Lipid profile	6 weeks
	Glucose levels (fasting)	6 weeks
	Serum insulin	6 weeks
	Insulin sensitivity	‐
	Socioeconomic effects	‐
Chantelau 1985	HbA1c	4 weeks
	Body weight (kg)	4 weeks
	Adverse events	‐
	Diabetes complications	‐
	All‐cause mortality	‐
	Health‐related quality of life	‐
	Anthropometric measures other than body weight (kg)	‐
	Lipid profile	4 weeks
	Glucose levels (postprandial)	4 weeks
	Serum insulin	‐
	Insulin sensitivity	‐
	Socioeconomic effects	‐
Nehrling 1985	HbA1c	9, 17, 18 weeks
	Body weight (kg)	‐
	Adverse events	18 weeks
	Diabetes complications	‐
	All‐cause mortality	‐
	Health‐related quality of life	‐
	Anthropometric measures other than body weight (kg)	‐
	Lipid profile	‐
	Glucose levels (fasting and postprandial)	9, 17, 18 weeks
	Serum insulin	‐
	Insulin sensitivity	‐
	Socioeconomic effects	‐
Stern 1976	HbA1c	‐
	Body weight (kg)	13 weeks
	Adverse events	13 weeks
	Diabetes complications	‐
	All‐cause mortality	‐
	Health‐related quality of life	‐
	Anthropometric measures other than body weight (kg)	‐
	Lipid profile	13 weeks
	Glucose levels (fasting)	4, 8, 13 weeks
	Serum insulin	‐
	Insulin sensitivity	‐
	Socioeconomic effects	‐
‐: denotes not reported HbA1c: glycosylated haemoglobin A1c