Trial ID	Intervention(s) and comparator(s)	Participants included in analysis (N)	Participants with a specific adverse event (description)	Participants with at least 1 specific adverse event (N)	Participants with at least 1 specific adverse event (%)
Ensor 2015	I: sucralose	207	(1) Hypoglycaemia (2) Pancreatitis (3) GI disturbances	(1) 0 (2) 0 (3) ‐	(1) 0 (2) 0 (3) ‐
	C: D‐tagatose	185	(1) Hypoglycaemia (2) Pancreatitis (3) GI disturbances	(1) 0 (2) 0 (3) ‐	(1) 0 (2) 0 (3) ‐
Barriocanal 2008	I: steviol glycoside	23	(1) Abdominal fullnessa (2) Headachea (3) Dizzinessa (4) Nauseaa (5) Astheniaa	(1) ‐ (2) ‐ (3) ‐ (4) ‐ (5) ‐	(1) ‐ (2) ‐ (3) ‐ (4) ‐ (5) ‐
	C: placebo	23	‐	(1) (2)	(1) (2)
Maki 2008	I: rebaudioside A	60	(1) Influenza‐like symptoms (2) Gastroenteritis (3) Gastrointestinal haemorrhage (4) Cyst (5) Hypoglycaemic episodes	(1) 1 (2) 1 (3) 1 (4) 1 (5) ‐	(1) 1.7 (2) 1.7 (3) 1.7 (4) 1.7 (5) ‐
	C: placebo	62	(1) Gastroenteritis (2) Fracture (3) Bronchitis (4) Hypoglycaemic episodes	(1) 1 (2) 1 (3) 1 (4) ‐	(1) 1.6 (2) 1.6 (3) 1.6 (4) ‐
Grotz 2003	I: sucralose	67	‐	‐	‐
	C: placebo	69	‐	‐	‐
Colagiuri 1989	I: aspartame	‐	‐	‐	‐
	C: sucrose	‐	‐	‐	‐
Cooper 1988	I: saccharin and starch	‐	‐	‐	‐
	C: sucrose	‐	‐	‐	‐
Chantelau 1985	I: sodium‐cyclamate	‐	‐	‐	‐
	C: sucrose	‐	‐	‐	‐
Nehrling 1985	I: aspartame	30	(1) Headaches (2) Constipation (3) Itching (4) Sinus congestion (5) Gastroenteritis (6) Severe diarrhoea	(1) 1 (2) 2 (3) 1 (4) 1 (5) 1 (6) 1	(1) 3.3 (2) 6.7 (3) 3.3 (4) 3.3 (5) 3.3 (6) 3.3
	C: placebo (cornstarch)	33	(1) Eczema (2) Dizziness (3) Eye twitching (4) Blurred vision (5) Foot pain (6) Nausea (7) Musculoskeletal pain (8) Rash (9) Itching (10) Ketoacidosis (11) Diarrhoea (12) Loose stools (13) Less frequent stools (14) Constipation (15) General malaise (16) Dry skin (17) Gastroenteritis	(1) 1 (2) 1 (3) 1 (4) 1 (5) 1 (6) 3 (7) 1 (8) 2 (9) 2 (10) 1 (11) 1 (12) 1 (13) 1 (14) 1 (15) 1 (16) 1 (17) 1	(1) 3.0 (2) 3.0 (3) 3.0 (4) 3.0 (5) 3.0 (6) 9.1 (7) 3.0 (8) 6.1 (9) 6.1 (10) 3.0 (11) 3.0 (12) 3.0 (13) 3.0 (14) 3.0 (15) 3.0 (16) 3.0 (17) 3.0
Stern 1976	I: aspartame	36	(1) Nausea (2) Constipation (3) Diarrhoea (4) Loss of appetite (5) Nervousness (6) Reticulum cell sarcoma	(1) 1 (2) 2 (3) 3 (4) 1 (5) 2 (6) 1	(1) 2.8 (2) 5.6 (3) 8.3 (4) 2.8 (5) 5.6 (6) 2.8
	C: placebo	33	(1) Cramps (2) Nausea (3) Constipation (4) Loss of appetite (5) Nervousness	(1) 2 (2) 1 (3) 5 (4) 1 (5) 2	(1) 6.1 (2) 3.0 (3) 15.2 (4) 3.0 (5) 6.1
‐: denotes not reported aNot specified whether participants in the intervention or the control group experienced this specific adverse event. C: comparator; GI: gastrointestinal; I: intervention; N: number of participants.