Table 2.
Hexapeptides of immunologic relevance shared between SARS-CoV-2 and GBS-related proteins as catalogued in the Immune Epitope Database (IEDB; www.iedb.org)12
Shared 6-mer |
SARS-CoV-2 protein |
Human proteins [UniProt-ID; Gene] |
Epitopes [IEDB-ID; Protein; Organism] |
---|---|---|---|
KDKKKK |
Nucleocapsid Phosphoprotein |
Heat shock protein 90-beta [P08238; HSP90AB1] Putative heat shock protein 90-beta 2 [Q58FF8; HSP90AB2P] |
KDKKKKTDEAQPLPQRQKKQ [30186; Nucleoprotein; SARS-CoV] EPKKDKKKKTDEAQPL [13680; Nucleoprotein; SARS-CoV] KTFPPTEPKKDKKKK [33669; Nucleoprotein; SARS-CoV] TEPKKDKKKKTDEAQPLPQRQKK + ACET(T1) [63494; Nucleoprotein; SARS-CoV] YKTFPPTEPKKDKKKK [74517; Nucleoprotein; SARS-CoV] |
EIPKEE |
Orf1ab Polyprotein |
60 kDa heat shock protein, mitochondrial [P10809; HSPD1] |
VVTEIPKEEKDPGM [112717; 60 kDa heat shock protein; Homo sapiens] |
Each row presents one shared hexamer (first column), the SARS-CoV-2 protein (second column), the human GBS-related protein(s) (third column), and the experimentally validated immunogenic epitopes containing the same hexamer (last column)