Table 4.

Cohorts in which blood flow was examined after SAH

Species	SAH method	Time after SAH	Measurement technique	Regions examined	Lowest perfusion (% of control)	Worsening over time	Refs.
Mouse	PCI	2 days	LSF, MRI	MCA territory (LSF); forebrain, midbrain, hindbrain (MRI)	77% in MCA territory 46% in forebrain	–	[43]
Mouse	EVP	1–3 days	OCT	Cerebral cortex	83% on day 3 in MCA territory	Yes	[14]
Rat	CMI	3–5 days	PW-MRI	?	56% on day 5	No	[16]
Rat	CMI	3 min–5 days	H2 clearance	Parietal, occipital, cerebellar cortex	60% on day 0 globally	No	[53]
Rat	CMI	3 h–14 days	14C autoradiography	Whole brain, frontal and parieto-occipital cortex, diencephalon, brainstem, cerebellum	No hypoperfusiona	No	[52]
Rat	PCI	1 h–4 days	14C autoradiography	Cerebral cortex	40% on day 2	Yes	[15]
Rat	PCI	3 days	14C autoradiography	Cerebral cortex	50%	–	[69]
Rat	EVP	1 h–9 days	MRI	Single slice 0.5 cm anterior to bregma	88% on day 2 ipsilateral to EVPa	No	[22]
Rabbit	CMI	6 days	H2 clearance	Cerebral cortex (bilateral frontal and parietal)	130%a	–	[87]
Dog	CMI	1–8 days	Microspheres	Cerebral cortex, cerebellum, pons, medulla	75% on day 8 in pons and medullaa	Yes	[13]
Dog	CMI	7 days	H2 clearance	Cerebral (occipital) cortex	57%	–	[108]
Dog	CMI	5 days	Microspheres	Cerebral cortex, cerebellum, brain stem	No hypoperfusiona	–	[109]
Dog	CMI	8 days	Microspheres	Cerebral cortex, cerebellum, brain stem	No hypoperfusiona	–	[109]
Primate	PVC	7 days	H2 clearance	Cerebral cortex	44% in frontal lobeb	–	[134]
Primate	PVC	7 days	133Xe clearance	Cerebral cortex	88% in right hemisphereb	–	[128]
Primate	PVC	7–14 days	133Xe clearance	Cerebral cortex	No hypoperfusionb	No	[127]
Primate	PCI	0–21 days	133Xe clearance	Cerebral cortex	No hypoperfusionb	No	[144]
Primate	PCI	7 days	133Xe clearance	Cerebral cortex	No hypoperfusionb	–	[143]

Cohorts are sorted by species followed by SAH method. Region with lowest perfusion is also indicated when specified in the report

^aNo statistical difference compared with sham

^bNo comparison with sham

CMI cisterna magna blood injection ×1–3, EVP endovascular perforation of internal carotid artery terminus, LSF laser speckle flowmetry, MRI magnetic resonance imaging, OCT optical coherence tomography-based microangiography, PCI prechiasmatic blood injection, PVC perivascular clot placement, PW-MRI perfusion weighted magnetic resonance imaging using masseter muscle to calculate relative regional CBF and CBV, SAH subarachnoid hemorrhage, ? not specified, ¹³³Xe intraarterial ¹³³Xenon clearance