Table 5.

Cohorts in which delayed neurological deficits were examined after experimental SAH

Species	SAH method	Neurological assessment method	DND rate	Onset of DND (days after SAH)	Neurological signs	Refs.
Rat	CMI	Grade based on motor function	?	3–5	Average grade worsened	[16]
Rabbit	CMI	Grade based on consciousness and activity	2/7 (29%)	4, 6	Average grade worsened	[90]
Cat	CMI	Grade based on consciousness and activity	6/21 (29%)	3–5	Average grade worsened	[99]
Pig	CMI	Qualitative based on motor function, consciousness and activity	4/8 (50%)	3–4	Unable to walk (n = 2), paraparesis (n = 1), loss of appetite followed by forelimb paresis (n = 1)	[126]
Primate	PVC	Qualitative based on consciousness	1/8 (13%)	8	Reduced level of consciousness, death	[140]
Primate	PVC	Qualitative based on consciousness and activity	2/7 (29%)	5–6	Decreased activity (n = 1), reduced level of consciousness (n = 1)	[134]
Primate	PVC	Qualitative based on motor deficit	1/8 (13%)	5	Hemiparesis	[131]
Primate	PVC	Qualitative based on motor deficit	1/12 (8%)	5	Hemiparesis	[130]
Primate	PVC	Qualitative based on motor deficit	2/8 (25%)	3, 5	Ataxia, death (n = 1), hemiparesis followed by contralateral monoparesis (n = 1)	[129]
Primate	PVC	Qualitative based on motor deficit	1/15 (7%)	4	Hemiparesis	[127]
Primate	PCI	Qualitative based on motor deficit, consciousness and activity	2/25 (8%)	Days 4 and 17	Unsteadiness and drowsiness (n = 1), apathy (n = 1)	[144]

Cohorts are sorted by species followed by SAH method. DND rate indicates % of animals in the cohort that developed DND

CMI cisterna magna blood injection ×1–3, DND delayed neurological deficits, PCI prechiasmatic blood injection, PVC perivascular clot placement, SAH subarachnoid hemorrhage, ? not reported