Table 7.
Species | SAH method | Time of assessment | Method of assessment | Findings | Region | Refs. |
---|---|---|---|---|---|---|
Mouse | EVP | 2 h, 3 days | MRI | New or larger infarct on day 3 in 33% (5/15) of animals | C | [18] |
Mouse | EVP | 3 h, 3 days | MRI | New or larger infarct on day 3 in 30% (3/10) of animals | C | [19] |
Mouse | EVP | 1, 3 days | MRI | New or larger infarct on day 3 in 50% (4/8) of animals | C | [20] |
Mouse | EVP | 1, 3 days | MRI | New or larger infarct on day 3 in 50% (5/10) of animals | C | [21] |
Rat | EVP | 1 h, 2, 9 days | MRI | Average infarct volume doubled on day 2 | C | [22] |
Rat | EVP | 1, 3 days | MRI | Average infarct volume increased by 29 mm3 on day 3 | C, SC, H | [23] |
Dog | CMI | ? | H&E | Infarct in 29% (4/14) of animals | CBL | [120] |
Primate | PVC | 7 days | MRI | Infarct in 100% (2/2) of animals | C, SC | [122] |
Primate | PVC | 8 days | Autopsy | Infarct in 13% (1/8) of animals | C | [140] |
Primate | PVC | 5 days | CT | Infarct in 13% (1/8) of animals | C | [131] |
Primate | PVC | 5 days | MRI | Infarct in 8% (1/12) of animals | C | [130] |
Primate | PVC | 5, 7 days | MRI, CT, autopsy | Infarct in 25% (2/8) of animals on day 5 or 7 | C, CBL | [129] |
Primate | PVC | 7 days | CT | Infarct in 7% (1/15) of animals | C | [127] |
Studies are sorted based on type of injury, followed by species and subarachnoid hemorrhage method
C cortex, CBL cerebellum, CMI cisterna magna blood injection ×1–3, CT computed tomography, EVP endovascular perforation of internal carotid artery terminus, FJ fluoro-Jade staining, H hippocampus, MRI magnetic resonance imaging, PCI prechiasmatic blood injection, PVC perivascular clot placement, SAH subarachnoid hemorrhage, SC subcortex