Table 3.
Relationship between expression levels of DDX60 and clinical indicators.
Training data (n = 350) | Validation data (n = 350) | |||||||
---|---|---|---|---|---|---|---|---|
High | Low | X 2 | p values | High | Low | X 2 | p values | |
Radiotherapy | 0.185 | 0.667 | 1.548 | 0.214 | ||||
Yes | 100 | 95 | 113 | 97 | ||||
No | 75 | 80 | 65 | 75 | ||||
Age | 0.561 | 0.454 | 0.175 | 0.675 | ||||
≥60 | 79 | 87 | 84 | 86 | ||||
<60 | 96 | 88 | 94 | 86 | ||||
History of other malignancies | 0.000 | 1.000 | 0.084 | 0.772 | ||||
Yes | 7 | 7 | 10 | 12 | ||||
No | 168 | 168 | 167 | 160 | ||||
Histologic type | 1.467 | 0.480 | 2.829 | 0.243 | ||||
IDC | 122 | 110 | 116 | 113 | ||||
MBC | 12 | 16 | 21 | 12 | ||||
ILC | 39 | 44 | 38 | 44 | ||||
First surgical procedure | 0.701 | 0.873 | 1.211 | 0.750 | ||||
Lumpectomy | 40 | 43 | 40 | 42 | ||||
Modified radical | ||||||||
Mastectomy | 58 | 62 | 59 | 53 | ||||
Others | 33 | 31 | 25 | 31 | ||||
A simple mastectomy | 34 | 29 | 40 | 36 | ||||
T stage | 1.091 | 0.296 | 0.186 | 0.666 | ||||
T3/T4 | 24 | 32 | 27 | 30 | ||||
T1/T2 | 151 | 142 | 151 | 142 | ||||
N stage | 0.675 | 0.411 | 0.156 | 0.693 | ||||
N2/N3 | 34 | 27 | 36 | 30 | ||||
N0/N1 | 140 | 146 | 141 | 136 | ||||
M stage | 0.070 | 0.791 | 0.002 | 0.963 | ||||
M1 | 5 | 3 | 1 | 2 | ||||
M0 | 154 | 146 | 153 | 144 | ||||
ER status by IHC | 0.197 | 0.657 | 0.867 | 0.352 | ||||
Positive | 133 | 138 | 138 | 128 | ||||
Negative | 34 | 30 | 27 | 34 | ||||
PR status by IHC | 0.041 | 0.840 | 3.496 | 0.062 | ||||
Positive | 118 | 116 | 126 | 107 | ||||
Negative | 49 | 52 | 38 | 53 | ||||
HER2 status by IHC | 2.748 | 0.253 | 2.706 | 0.259 | ||||
Positive | 42 | 30 | 38 | 25 | ||||
Overexpression | 24 | 27 | 20 | 20 | ||||
Negative | 82 | 92 | 93 | 99 | ||||
Chemotherapy | 4.228 | 0.040 | 0.537 | 0.464 | ||||
Yes | 155 | 140 | 156 | 146 | ||||
No | 20 | 35 | 21 | 26 |
Note. Abbreviations are the same as in Table 1.