a: Venn diagram of the number differentially expressed genes between sexes. F = Female. M = Male. DEG = differentially expressed genes. Ddx3y, Kdm5d, Eif2s3y, and Uty are upregulated in females of both genotypes compared to males, while Eif2s3x, Ddx3x, Kdm6a, Kdm5c, Jpx, and Xist are downregulated.
b: Venn diagram of the number of differentially expressed genes between genotypes. ArKO = Aromatase knockout. WT = Wild-type. DEG = differentially expressed gene. Pts, Gldn, Cryab, and Nxpe4 are downregulated in ArKO of both sexes, compared to WT, while Cyp19a1 is upregulated.