Table 4.
Significantly enriched interactions of DEGs indicating the gene ontology and biological pathways (KEGG & Reactome) in WT males v. WT females.
| Description | FDR | |
|---|---|---|
| GO: molecular function | Histone demethylase activity | 2.10845E–05 |
| Steroid hormone receptor binding | 0.003656028 | |
| Estrogen response element binding | 0.006161726 | |
| Nuclear hormone receptor binding | 0.006985698 | |
| Estrogen receptor activity | 0.00720369 | |
| hormone receptor binding | 0.00854285 | |
| GO: biological processes | Histone demethylation | 4.97867E–05 |
| Regulation of macromolecule metabolic process | 0.000254213 | |
| Regulation of phospholipase C activity | 0.0008599 | |
| Regulation of lipase activity | 0.003559273 | |
| Response to steroid hormone | 0.004524849 | |
| Response to estrogen | 0.004724675 | |
| Regulation of circadian rhythm | 0.006080162 | |
| Intracellular steroid hormone receptor signaling pathway | 0.007111892 | |
| Steroid hormone mediated signaling pathway | 0.010956526 | |
| chromatin organization | 0.012145584 | |
| Hormone-mediated signaling pathway | 0.013819596 | |
| Negative regulation of triglyceride metabolic process | 0.015261211 | |
| Cellular response to steroid hormone stimulus | 0.017041363 | |
| Biological pathways (Reactome) | HDMs demethylate histones | 6.88327126245209E–07 |
| Chromatin organization | 1.42112E–06 | |
| RUNX1 regulates estrogen receptor mediated transcription | 0.017513604 | |
| Biological pathways (KEGG) | Transcriptional misregulation in cancer | 0.002297158 |
| Melanoma | 0.004863766 | |
| Prostate cancer | 0.006409001 | |
| Endocrine resistance | 0.006409001 | |
| Thyroid hormone signaling pathway | 0.008216614 | |
| Breast cancer | 0.01121615 | |
| MicroRNAs in cancer | 0.01121615 |