Table 5.
Significantly enriched interactions of DEGs indicating the gene ontology and biological pathways (KEGG & Reactome) in KO males v. ArKO females.
| Description | FDR | |
|---|---|---|
| GO: molecular function | Histone demethylase activity | 2.10845E–05 |
| Steroid hormone receptor binding | 0.003656028 | |
| Type 1 metabotropic glutamate receptor binding | 0.003724315 | |
| Estrogen response element binding | 0.006161726 | |
| Nuclear hormone receptor binding | 0.006985698 | |
| Estrogen receptor activity | 0.00720369 | |
| Hormone receptor binding | 0.00854285 | |
| GO: biological processes | Histone demethylation | 4.97867E–05 |
| Cellular macromolecule biosynthetic process | 8.52132E–05 | |
| Macromolecule metabolic process | 0.000153116 | |
| Aromatic compound biosynthetic process | 0.000348629 | |
| Development of primary male sexual characteristics | 0.000563921 | |
| Regulation of primary metabolic process | 0.000733981 | |
| Male sex differentiation | 0.000815365 | |
| Regulation of phospholipase C activity | 0.0008599 | |
| Developmental growth | 0.002098432 | |
| Regulation of lipase activity | 0.003559273 | |
| Response to steroid hormone | 0.004524849 | |
| Ovulation cycle | 0.004537605 | |
| Cellular hormone metabolic process | 0.005381536 | |
| Histone modification | 0.005591953 | |
| Regulation of circadian rhythm | 0.006080162 | |
| Development of primary female sexual characteristics | 0.007830935 | |
| Female sex differentiation | 0.009139693 | |
| Response to estradiol | 0.009148897 | |
| Biological pathways (Reactome) | HDMs demethylate histones | 6.88327126245209E–07 |
| Chromatin modifying enzymes | 1.42112E–06 | |
| Chromatin organization | 1.42112E–06 | |
| Negative regulation of the PI3K/AKT network | 0.01699868 | |
| NFG and proNGF binds to p75NTR | 0.01699868 | |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.01699868 | |
| Signal transduction | 0.01699868 | |
| RUNX1 regulates estrogen receptor mediated transcription | 0.017513604 | |
| Neutrophil degranulation | 0.019035096 | |
| Axonal growth stimulation | 0.019035096 | |
| Biological pathways (KEGG) | Focal adhesion | 0.002297158 |
| Pathways in cancer | 0.002297158 | |
| Transcriptional misregulation in cancer | 0.002297158 | |
| Human cytomegalovirus infection | 0.003347549 | |
| Glioma | 0.004863766 | |
| Melanoma | 0.004863766 | |
| PI3K-Akt signaling pathway | 0.004863766 | |
| Prolactin signaling pathway | 0.004863766 | |
| Endocrine resistance | 0.006409001 | |
| Thyroid hormone signaling pathway | 0.008216614 | |
| MicroRNAs in cancer | 0.01121615 | |
| JAK-STAT signaling pathway | 0.012700471 | |
| RNA transport | 0.012700471 | |
| Calcium signaling pathway | 0.015053718 | |
| Proteoglycans in cancer | 0.015382804 | |
| Rap1 signaling pathway | 0.01612003 | |
| Regulation of actin cytoskeleton | 0.01612003 | |
| Viral carcinogenesis | 0.01612003 | |
| Ras signaling pathway | 0.017199112 |