Table 6.

Significantly enriched interactions of DEGs indicating the gene ontology and biological pathways (KEGG & Reactome) in Male WT v. ArKO mice.

	Description	FDR
GO: Molecular Function
	lipid binding	0.003086564
	prostaglandin binding	0.003452799
	6-pyruvoyltetrahydropterin synthase activity	0.003452799
	neuropeptide Y receptor activity	0.018157161
	peptide YY receptor activity	0.010641921
GO: Biological Process
	glial cell migration	0.000348694
	neurogenesis	0.000686558
	locomotion	0.000792012
	metabolic process	0.0014716
	nervous system development	0.002011761
	regulation of hormone levels	0.002758
	regulation of astrocyte differentiation	0.003388127
	cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration	0.006503613
	neuron differentiation	0.006503613
	aging	0.00761918
	hormone secretion	0.008085701
	hormone transport	0.008424296
	regulation of glial cell differentiation	0.008963381
	neuronal-glial interaction involved in cerebral cortex radial glia guided migration	0.009730318
	cerebellum structural organization	0.009730318
	hindbrain structural organization	0.009730318
	regulation of primary metabolic process	0.009730318
	cellular hormone metabolic process	0.009959859
	estradiol secretion	0.011722735
	response to drug	0.011818741
	feeding behavior	0.012703111
	aromatic compound biosynthetic process	0.013689053
	androgen catabolic process	0.013769906
	motor neuron migration	0.017303974
	Post-synapse organization	0.017605926
	tetrahydrobiopterin biosynthetic process	0.018216943
	tetrahydrobiopterin metabolic process	0.019688381
Biological Pathways (Reactome)
	Class A/1 (Rhodopsin-like receptors)	0.016216258
	Metabolism	0.016216258
	G alpha (i) signalling events	0.018546984
	GPCR ligand binding	0.018546984
Biological Pathways (KEGG)
	Longevity Regulating Pathway-multiple species	0.014854072