Table 2.

Quality assessment.

Author	Selection bias			Performance bias		Detection bias		Attrition bias	Reporting bias	Other biases
	Random sequence generation	Baseline characteristics	Allocation concealment	Random housing	Blinding	Random outcome assessment	Outcome assessor blinding	Incomplete outcome data	Selective outcome report	Other sources of bias
Aviello, et al. 2012 [7]	Unclear	Yes	Unclear	Yes	Unclear	No	Unclear	Yes	Yes	Yes
Borrelli, et al. 2014 [38]	Unclear	Yes	Unclear	Yes	Unclear	No	Unclear	Yes	Yes	Yes
Izzo, et al. 2008 [35]	Unclear	Yes	Unclear	Yes	Unclear	No	Unclear	Yes	Yes	No
Kargl, et al. 2013[[28]	Unclear	Yes	Unclear	Yes	Unclear	No	Unclear	Yes	Yes	Yes
Pagano, et al. 2017 [56]]	Unclear	Yes	Unclear	Yes	Unclear	No	Unclear	Yes	Yes	No
Romano, et al. 2014 [8]	Unclear	Yes	Unclear	Yes	Unclear	No	Unclear	Yes	Yes	No
Santoro, et al. 2009 [57]	Unclear	Yes	Unclear	Yes	Unclear	No	Unclear	Yes	Yes	Yes
Thapa, et al. 2012 [58]	Unclear	Yes	Unclear	Yes	Unclear	No	Unclear	Yes	Yes	No

SYRCLE's risk of bias tool for animal studies [14].