Table 3. Adjusted Absolute Rates and Relative Risks of Total Cancer Detection and Invasive Cancer Detectiona.
| BI-RADS density | Total cancer detection rate | Invasive cancer detection rate | ||||||
|---|---|---|---|---|---|---|---|---|
| aAR (95% CI) | Difference (95% CI) | Relative risk (95% CI) | aAR (95% CI) | Difference (95% CI) | Relative Risk (95% CI) | |||
| DM | DBT | DM | DBT | |||||
| Baseline screening | ||||||||
| All women aged 40-49 y | 3.2 (2.7 to 3.9) | 4.4 (3.5 to 5.7) | 1.28 (0.38 to 2.39) | 1.41 (1.11 to 1.80) | 2.2 (1.7 to 2.7) | 3.1 (2.3 to 4.1) | 0.93 (0.21 to 1.83) | 1.44 (1.10 to 1.90) |
| All women aged 50-59 y | 5.9 (4.9 to 7.2) | 8.8 (6.3 to 12.6) | 2.89 (0.60 to 6.15) | 1.50 (1.10 to 2.08) | 4.2 (3.3 to 5.3) | 6.5 (4.7 to 8.8) | 2.28 (0.57 to 4.36) | 1.55 (1.13 to 2.09) |
| All women aged 60-79 y | 10.8 (9.3 to 12.9) | 15.1 (11.7 to 20.2) | 4.27 (0.75 to 8.54) | 1.42 (1.09 to 1.86) | 9.0 (7.4 to 11.2) | 12.3 (9.8 to 16.0) | 3.29 (0.41 to 6.40) | 1.40 (1.07 to 1.79) |
| Subsequent screening | ||||||||
| Aged 40-49 y | ||||||||
| Almost entirely fat | 1.6 (1.4 to 1.9) | 1.6 (1.1 to 2.1) | −0.08 (−0.52 to 0.41) | 0.95 (0.69 to 1.27) | 1.1 (1.0 to 1.3) | 1.1 (0.8 to 1.5) | −0.06 (−0.37 to 0.34) | 0.95 (0.69 to 1.30) |
| Scattered fibroglandular density | 2.2 (2.0 to 2.5) | 2.4 (1.9 to 2.9) | 0.19 (−0.34 to 0.78) | 1.08 (0.85 to 1.37) | 1.5 (1.3 to 1.7) | 1.6 (1.3 to 2.1) | 0.12 (−0.26 to 0.57) | 1.08 (0.83 to 1.40) |
| Heterogeneously dense | 2.5 (2.2 to 2.7) | 3.1 (2.5 to 3.9) | 0.68 (0.05 to 1.43) | 1.28 (1.02 to 1.61) | 1.6 (1.5 to 1.8) | 2.1 (1.7 to 2.7) | 0.51 (0.05 to 1.07) | 1.31 (1.03 to 1.67) |
| Extremely dense | 2.5 (2.2 to 2.9) | 2.7 (2.0 to 3.5) | 0.17 (−0.53 to 0.98) | 1.07 (0.79 to 1.42) | 1.4 (1.2 to 1.7) | 1.5 (1.1 to 2.2) | 0.09 (−0.39 to 0.80) | 1.06 (0.74 to 1.60) |
| Aged 50-59 y | ||||||||
| Almost entirely fat | 2.1 (1.9 to 2.5) | 2.3 (1.6 to 3.0) | 0.13 (−0.53 to 0.90) | 1.06 (0.76 to 1.45) | 1.6 (1.4 to 1.9) | 1.7 (1.3 to 2.4) | 0.12 (−0.34 to 0.73) | 1.08 (0.80 to 1.49) |
| Scattered fibroglandular density | 3.3 (3.1 to 3.6) | 4.0 (3.4 to 4.6) | 0.68 (0.08 to 1.35) | 1.21 (1.02 to 1.42) | 2.4 (2.2 to 2.6) | 3.0 (2.5 to 3.5) | 0.55 (0.04 to 1.12) | 1.23 (1.02 to 1.48) |
| Heterogeneously dense | 3.7 (3.4 to 4.0) | 5.3 (4.6 to 6.0) | 1.56 (0.90 to 2.31) | 1.42 (1.23 to 1.64) | 2.6 (2.4 to 2.9) | 3.9 (3.5 to 4.6) | 1.29 (0.73 to 1.97) | 1.49 (1.26 to 1.76) |
| Extremely dense | 3.7 (3.3 to 4.3) | 4.4 (3.3 to 6.0) | 0.71 (−0.46 to 2.28) | 1.19 (0.89 to 1.61) | 2.3 (2.0 to 2.7) | 2.8 (2.0 to 3.8) | 0.49 (−0.35 to 1.58) | 1.21 (0.86 to 1.72) |
| Aged 60-79 y | ||||||||
| Almost entirely fat | 3.8 (3.3 to 4.4) | 3.9 (2.9 to 5.1) | 0.15 (−0.85 to 1.33) | 1.04 (0.79 to 1.35) | 3.1 (2.7 to 3.6) | 3.1 (2.3 to 4.2) | 0.02 (−0.73 to 0.99) | 1.01 (0.77 to 1.33) |
| Scattered fibroglandular density | 5.5 (5.2 to 5.9) | 6.5 (5.7 to 7.4) | 1.00 (0.17 to 1.89) | 1.18 (1.03 to 1.35) | 4.3 (4.1 to 4.7) | 5.0 (4.4 to 5.8) | 0.64 (−0.06 to 1.41) | 1.15 (0.99 to 1.33) |
| Heterogeneously dense | 6.1 (5.7 to 6.5) | 8.5 (7.6 to 9.4) | 2.38 (1.54 to 3.23) | 1.39 (1.25 to 1.54) | 4.6 (4.3 to 5.1) | 6.5 (5.8 to 7.3) | 1.82 (1.01 to 2.66) | 1.39 (1.21 to 1.59) |
| Extremely dense | 5.9 (5.3 to 6.7) | 6.9 (5.5 to 8.7) | 0.97 (−0.54 to 2.82) | 1.16 (0.91 to 1.49) | 3.9 (3.4 to 4.6) | 4.4 (3.4 to 6.0) | 0.51 (−0.71 to 2.22) | 1.13 (0.84 to 1.59) |
Abbreviations: aAR, adjusted absolute rate; BI-RADS, Breast Imaging Reporting and Data System; DBT, digital breast tomosynthesis; DM, digital mammography.
a
Rates and relative risks are adjusted for the woman- and examination-level characteristics given in Table 1, including race/ethnicity, family history of breast cancer, history of prior biopsy, 5-year risk of breast cancer, time since prior mammogram, and year of examination.