1. Random‐effects metaregression: < 1000 mg vs 1000 mg, Paracetamol vs Placebo.

Outcome	Number of studies	Slope estimate	95% CI	Slope interpretation	P value
50% pain relief at 4 hours (using pain relief)	16	0.94	(0.36 to 1.52)	more pain relief for higher doses	0.001
50% pain relife at 6 hours (using pain relief)	13	1.14	(0.71 to 1.56)	more pain relief for higher doses	<0.001
50% pain relief at 4 hours (using pain intensity)	16	0.23	(‐0.84 to 1.30)	more pain relief for higher doses	0.67
50% pain relief at 6 hours (using pain intensity)	14	0.43	(‐0.15 to 1.01)	more pain relief for higher doses	0.15