Cooper 1988.

Methods	Randomised, parallel group, double blind study
Participants	165 participants randomised to 4 groups, withdrawals unclear (22 from all groups) Number randomised to intervention: male 7, female 29, mean age 24.6 Number randomised to placebo: male 11, female 29, mean age 24.7 Number of third molars removed: mean for intervention 1.4, mean for placebo 1.5 Baseline pain intensity: mean for intervention 2.4 (moderate 21, severe 15), mean for placebo 2.4 (moderate 25, severe 15) Setting ‐ outpatients ‐ single site (USA)
Interventions	Paracetamol 600 mg versus placebo Formulation: not stated Anaesthesia: LA or LA and SED
Outcomes	PI at 4 hours and 6 hours: categorical scale 0‐3 (none ‐ severe) PR at 4 hours and 6 hours: categorical scale 0‐4 (none ‐ complete) Global assessment: categorical scale 0‐4 (poor ‐ excellent) Total number of adverse events
Notes	Sponsored by Parke‐Davis
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear