| Methods |
Randomised, parallel group, double blind study |
| Participants |
107 participants randomised to 5 groups, withdrawals unclear (19 from all groups, 98 participants used in reporting of adverse events)
Number randomised to intervention: male 9, female 13, mean age 20.59, age range 17‐31
Number randomised to placebo: male 12, female 11, mean age 23.74, age range 16‐39
Number of third molars removed: mean for intervention 2.59, mean for placebo 2.09
Baseline pain intensity: mean for intervention 2.45, mean for placebo 2.39
Setting ‐ 2 sites, private dental practice, outpatients (USA) |
| Interventions |
Paracetamol 600 mg versus placebo
Formulation ‐ 1 tablet & 1 capsule
Anaesthesia: LA and GA |
| Outcomes |
PI at 4 hours and 6 hours: categorical scale 0‐3 (none ‐ severe)
PR at 4 hours and 6 hours: categorical scale 0‐4 (none ‐ complete)
Global assessment : categorical 0‐4 (poor ‐ excellent)
Adverse effects reported by number of patients with adverse events |
| Notes |
Sponsored by
Boots Company Ltd., G.H. Besselaar Associates |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
