Forbes 1990.

Methods	Randomised, parallel group, double blind study
Participants	206 participants randomised to 6 groups Number randomised to intervention: male 20, female 16, (5 withdrawals), mean age 22.5, age range 16‐46 Number randomised to placebo: male 18, female 16, (4 withdrawals), mean age 23.65, age range 16‐45 Number of third molars removed: mean for intervention 2.58, mean for placebo 2.35 Baseline pain intensity: mean for intervention 2.39 (moderate 22, severe 14), mean for placebo 2.32 (moderate 23, severe 11) Setting ‐ private dental practice outpatients (USA)
Interventions	Paracetamol 600 mg versus placebo Formulation: capsules Anaesthesia: LA and GA
Outcomes	PI at 4 hours and 6 hours: categorical scale 0‐3 (none ‐ severe) PR at 4 hours and 6 hours: categorical scale 0‐4 (none ‐ complete) Global assessment: categorical 0‐4 (poor ‐ excellent) Adverse effects table
Notes	Sponsored by Syntex Research
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	A ‐ Adequate