| Methods |
Randomised, parallel group, double blind study |
| Participants |
210 participants randomised to 4 groups, no withdrawals
Number randomised to intervention: male 20, female 43, mean age 23.3
Number of third molars removed/patient: (1/1), (2/6), (3/5), (4/51)
Number randomised to placebo: male 9, female 8, mean age 23.7
Number of wisdom teeth removed per patient: (1/1) (2/5) (3/3) (4/18)
Baseline pain intensity: mean for intervention 2.3 (moderate 47, severe 16), mean for placebo 2.2 (moderate 22, severe 5)
Setting ‐ University of Pennsylvania School of Dental Medicine ‐ outpatients (USA) |
| Interventions |
Paracetamol 1000 mg versus placebo
Formulation: caplets
Anaesthesia: LA or LA and SED |
| Outcomes |
PI at 4 hours and 6 hours: categorical 0‐3 (none ‐ severe)
PR at 4 hours and 6 hours: categorical 0‐4 (no relief ‐ complete relief)
Global assessment: categorical 0‐4 (poor ‐ excellent)
Adverse effects by total number of adverse events, and number of patients with adverse events |
| Notes |
Sponsored by
Whitehall‐Robins |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
