Kiersch 1994.

Methods	Randomised, parallel group, double blind study
Participants	232 participants enrolled in 3 groups Number randomised to intervention 91, withdrawals 4 (2 before and 2 after randomisation): male 72, female 17, mean age 23.1, age range 15‐39 Number of third molars removed/patient: (1/0), (2/0), (3/31), (4/54) Number randomised to placebo 47, withdrawals 2: male 35, female 10, mean age 24.7, age range 15‐39 Number of third molars removed/patient: (1/0), (2/0), (3/19), (4/26) Baseline pain intensity: mean for intervention and placebo categorical 2.12, VAS 58.35 Setting not stated (USA)
Interventions	Paracetamol 1000 mg versus placebo Formulation: capsules Anaesthesia: not stated
Outcomes	PI at 4 hours and 6 hours: categorical 0‐3 (none ‐ severe) PR at 4 hours and 6 hours: categorical 0‐4 (none ‐ complete), VAS 0‐100 mm (no pain ‐ worst pain I can imagine) Global assessment: categorical 0‐4 (poor ‐ excellent) Adverse effects reported by total number of adverse events, and by number of patients with adverse events
Notes	Sponsored by Syntex Research
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear