Seymour 1996.

Methods	Randomised, parallel group, double blind study
Participants	206 participants randomised to 5 groups Number randomised to intervention A, 1 withdrawal: male 12, female 28, mean age 23.8 Number randomised to intervention B, 1 withdrawal: male 12, female 28 mean age 27.7, 1 withdrawal Number randomised to placebo, 2 withdrawals: male 15, female 24, mean age 24.6 Number of third molars removed/patient: not stated Baseline pain intensity: mean for intervention A, VAS 54.9, mean for intervention B, VAS 54.2, mean for placebo VAS 56.5 Setting: not stated (UK)
Interventions	Intervention A: paracetamol 500 mg versus placebo Intervention B: paracetamol 1000 mg versus placebo Formulation: not stated Anaesthesia: GA
Outcomes	PI at 6 hours: VAS scale 0‐100 mm (no pain ‐ unbearable pain) Global assessment: categorical 0 ‐3 (very good ‐ very poor) but categories 1 & 2, and 4 & 5 not reported separately so unable to include data in tables Adverse effects ‐ none reported by any participants in any group
Notes	Sponsored ‐ unclear
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear