Seymour 2003.

Methods	Randomised, parallel group, double blind study
Participants	167 randomised to 3 groups, withdrawals unclear (14 from all groups) Number randomised to intervention: male 19, female 43, mean age 25.0 Number randomised to placebo: male 11, female 21, mean age 25.1 Number of third molars removed/patient: intervention ‐ (1/2), (2/14), (3/12), (4/34), placebo ‐ (1/3), (2/5), (3/9), (4/15) Baseline pain intensity: mean for intervention 50.6, mean for placebo 54.1 Setting not clear (2 sites, Cardiff and Hexham, UK)
Interventions	Paracetamol 1000 mg versus placebo Formulation: tablets Anaesthesia: GA
Outcomes	PI at 4 hours: VAS scale 0‐100 mm (none ‐ worst pain imaginable) PR: not stated Global assessment: categorical scale 1‐5 (very poor ‐ very good) Adverse effects table
Notes	Sponsored by Reckitt Benckiser Healthcare
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	A ‐ Adequate