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. 2007 Jul 18;2007(3):CD004487. doi: 10.1002/14651858.CD004487.pub2

Sunshine 1986.

Methods Randomised, parallel group, double blind study
Participants 182 participants randomised to 6 groups, no withdrawals (only patients with moderate to severe pain were randomised)
 Number randomised to intervention: male 6, female 24, mean age 21.9
 Number randomised to placebo: male 14, female 16, mean age 23
 Number of third molars removed: not stated
 Baseline pain intensity: mean for intervention 2.00, mean for placebo 2.00
 Setting: University of Puerto Rico School of Dentistry Clinic
Interventions Paracetamol 650 mg versus placebo
 Formulation: capsules
 Anaesthesia: LA
Outcomes PI at 4 hours and 6 hours: categorical scale 0‐3 (none ‐ severe)
 PR at 4 hours and 6 hours: categorical scale 0‐4 (none 0% ‐ complete 100%)
 Global assessment: categorical 0‐3 (poor ‐ excellent)
 Overall improvement 1‐7 (very much worse ‐ very much better)
 Adverse effects reported by number of patients with adverse events
Notes Sponsored by
 Upjohn
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Low risk A ‐ Adequate