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. Author manuscript; available in PMC: 2021 Jun 19.
Published in final edited form as: Circ Res. 2020 Jun 18;127(1):21–33. doi: 10.1161/CIRCRESAHA.120.316575

Figure 2. Major AF-associated genes and lines of evidence.

Figure 2

The figure illustrates AF-associated genes that were discovered through family based or gene-based studies. For each gene the lines of evidence are listed. The table includes the evidence from familial AF genetic analysis, whether coding variants in the gene are associated with AF, if the gene lies within an AF GWAS locus, whether loss-of-function variation is associated with AF, and functional evidence that has been reported for the gene in the context of AF.

Abbreviations: AF, atrial fibrillation; GWAS, genome-wide association study.