Table 1.
To date there are at least 138 AF loci identified in single variant testing with P-value < 5 × 10−8. The table below includes the most significant variant at each locus from the latest AF GWAS publications by Roselli et al.[28] or Nielsen et al.[29]. The listed genes are either the nearest gene(s) or the eGene. The eGene is defined as a gene with an eQTL to the variant at an AF GWAS locus and is highlighted in bold. The eGene is listed when it is the only eGene at that locus. Notably, only 18 out of 138 variants are associated with only one eGene.
| Rsid | Nearest Gene(s) or eGene | Rsid | Nearest Gene(s) or eGene | Rsid | Nearest Gene(s) or eGene |
|---|---|---|---|---|---|
| rs187585530 | UBE4B | rs716845 | KCNN2 | rs1822273 | NAV2 |
| rs880315 | CASZ1 | rs2012809 | FBN2, SLC27A6 | rs949078 | SORL1, MIR100HG |
| rs7529220 | HSPG2, CELA3B | rs34750263 | WNT8A, NME5 | rs76097649 | KCNJ5 |
| rs2885697 | SCMH1 | rs174048 | ARHGAP26, NR3C1 | rs6490029 | CUX2 |
| rs11590635 | AGBL4 | rs12188351 | SLIT3 | rs10842383 | LINC00477, BCAT1 |
| rs56202902 | FAF1 | rs6882776 | NKX2–5 | rs113819537 | SSPN |
| rs146518726 | C1orf185 | rs73366713 | ATXN1 | rs12809354 | PKP2 |
| rs12044963 | KCND3 | rs34969716 | KDM1B | rs7978685 | NACA |
| rs4484922 | CASQ2 | rs1307274 | C6orf1, NUDT3 | rs35349325 | BEST3 |
| rs79187193 | GJA5 | rs3176326 | CDKN1A | rs11180703 | KRR1, PHLDA1 |
| rs11264280 | KCNN3, PMVK | rs6907805 | CGA, ZNF292 | rs883079 | TBX5 |
| rs72700114 | METTL11B, LINC01142 | rs210632 | GOPC | rs12810346 | TBX5-AS1, TBX3 |
| rs608930 | GORAB, PRRX1 | rs17079881 | SLC35F1 | rs10773657 | HIP1R |
| rs10753933 | PPFIA4 | rs13191450 | GJA1, HSF2 | rs12298484 | DNAH10 |
| rs4951261 | NUCKS1 | rs12208899 | LINC00326, EYA4 | rs6560886 | FBRSL1 |
| rs6546620 | KIF3C | rs117984853 | UST | rs9580438 | LINC00540, BASP1P1 |
| rs6742276 | XPO1 | rs11768850 | SUN1 | rs35569628 | CUL4A |
| rs2540949 | CEP68 | rs55734480 | DGKB | rs28631169 | MYH7 |
| rs10165883 | SNRNP27 | rs6462078 | CREB5 | rs2145587 | AKAP6 |
| rs72926475 | REEP1, KDM3A | rs74910854 | PMS2P2 | rs73241997 | SNX6,CFL2 |
| rs28387148 | GYPC | rs11773884 | CDK6 | rs2738413 | SYNE2 |
| rs67969609 | TEX41 | rs62483627 | COG5 | rs74884082 | DPF3 |
| rs12992412 | MBD5 | rs11773845 | CAV1 | rs10873299 | LRRC74, IRF2BPL |
| rs56181519 | WIPF1 | rs55985730 | OPN1SW | rs147301839 | MYZAP |
| rs35504893 | FKBP7 | rs7789146 | KCNH2 | rs62011291 | USP3 |
| rs295114 | SPATS2L | rs35620480 | LINC00208, GATA4 | rs12591736 | TLE3, UACA |
| rs35544454 | ERBB4 | rs7508 | ASAH1 | rs74022964 | HCN4, REC114 |
| rs6810325 | MKRN2 | rs7846485 | XPO7 | rs12908004 | LINC00927, ARNT2 |
| rs73032363 | THRB | rs62521286 | FBXO32 | rs12908437 | IGF1R |
| rs6790396 | SCN10A | rs35006907 | MTSS1, LINC00964 | rs2286466 | RPL3L |
| rs2306272 | SLC25A26 | rs7460121 | MIR30B | rs2359171 | ZFHX3 |
| rs17005647 | FRMD4B | rs6993266 | PTK2 | rs7225165 | YWHAE, CRK |
| rs7632427 | EPHA3 | rs4977397 | SLC24A2, MLLT3 | rs8073937 | POLR2A, TNFSF12 |
| rs17490701 | PHLDB2 | rs4385527 | C9orf3 | rs72811294 | MYOCD |
| rs1278493 | PPP2R3A | rs4743034 | ZNF462 | rs11658278 | ZPBP2 |
| rs4855075 | GNB4 | rs10760361 | PSMB7 | rs242557 | MAPT |
| rs60902112 | XXYLT1 | rs2274115 | LHX3 | rs76774446 | GOSR2 |
| rs9872035 | PAK2 | rs2296610 | NEBL | rs7219869 | KCNJ2, CASC17 |
| rs3822259 | WDR1 | rs7919685 | NRBF2 | rs12604076 | CYTH1 |
| rs1458038 | PRDM8, FGF5 | rs7096385 | SIRT1 | rs9953366 | SMAD7 |
| rs3960788 | UBE2D3 | rs60212594 | SYNPO2L | rs8088085 | MEX3C |
| rs2129977 | PITX2, C4orf32 | rs11001667 | C10orf11 | rs2145274 | CASC20, BMP2 |
| rs55754224 | CAMK2D | rs1044258 | C10orf76 | rs7269123 | C20orf166 |
| rs10213171 | ARHGAP10 | rs11598047 | NEURL | rs2834618 | LOC100506385 |
| rs10520260 | HAND2-AS1 | rs2047036 | SH3PXD2A | rs465276 | TUBA8 |
| rs6596717 | LOC102467213, EFNA5 | rs10749053 | RBM20 | rs133902 | MYO18B |