Fossum 2011.

Study characteristics
Methods	Truly randomised trial: not stated Time of randomisation: at conclusion of initial surgery before closure Blinding: assessor blinded Power calculation: not used ITT: no Location: multi‐centre trial in USA Timing and duration: not stated
Participants	Inclusion criteria: non‐pregnant women between 18 and 49 years of age scheduled to undergo laparoscopic myomectomy for resection of at least 1 uterine fibroid (N = 41) Exclusion criteria: intraoperatively if infection or abscess identified, if entry into endometrial cavity or bowel lumen noted, if adhesiolysis involving bowel wall performed, or if concurrent, non‐gynaecological procedure was performed Number undergoing second‐look laparoscopy: 38 Timing second‐look laparoscopy: 4 to 12 weeks after initial surgery
Interventions	Hyaluronic acid and carboxymethylcellulose versus no treatment
Outcomes	Presence or absence of adhesions, extent and severity at 14 intra‐abdominal and pelvic sites at initial surgery and second‐look laparoscopy (mAFS score) Adverse effects
Notes	Funded by Genzyme Clinicaltrials.gov register number: NCT00624390
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No comment on randomisation method
Allocation concealment (selection bias)	Unclear risk	No comment on allocation concealment
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to provide judgement
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Surgeries videotaped and reviewed by blinded investigator
Incomplete outcome data (attrition bias) All outcomes	Low risk	No issues identified
Selective reporting (reporting bias)	Low risk	All outcomes specified in trial registry reported ‐ NCT00624390
Other bias	High risk	Data were only displayed in graphs, with no indication of SD, SE, CI or P value