Jansen 1990.

Study characteristics
Methods	Truly randomised trial (random number sequence) Timing of randomisation: not stated Factorial design Power calculation: yes Location: Sydney, Australia Timing and duration: not stated
Participants	Infertile women undergoing open gynaecological microsurgery Condition: pelvic adhesions, endometriosis, or both Surgery performed: adhesiolysis; excision of endometriosis Pre‐existing adhesions: 75 women Age: not stated Duration infertility: not stated Infertility work‐up: not stated Number randomly assigned: 95 (no exclusions stated) Number analysed: 93 for comparison 1; 95 for comparison 2 Timing second‐look laparoscopy: 10 or 12 days postoperative Blinding at second‐look laparoscopy: not stated
Interventions	1. Promethazine versus no treatment Route of administration: systemic (oral and IM) Dosage/volume: 50 mg oral 6 hours preoperatively and 50 mg IM intraoperatively 2. Postoperative steroids versus no treatment Route of administration: systemic (oral) Dosage/volume: postoperative prednisone 25 mg oral twice a day for 4 days, then 25 mg daily until SLL Other adjuvants: all women received systemic preoperative (50 mg prednisone 8 hours preoperatively) and intraoperative (24 mg dexamethasone IV) steroids Prophylactic antibiotics: yes
Outcomes	Analysed in review Adhesions at second‐look laparoscopy Improvement; no change; deterioration Other outcomes: adhesions at second‐look laparoscopy Change in score
Notes	Adhesion scoring system used Modified American Fertility Society endometriosis scoring system (range 0 to 27) Data obtained from review article and investigator himself Some study information supplied in correspondence from study authors
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Stated that study was randomised, but method not stated
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not stated
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not stated
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Not stated
Selective reporting (reporting bias)	Unclear risk	Data presented in full for all outcomes specified, however, no study protocol or trial registry identified for comparison
Other bias	Low risk