Lundorff 2005.

Study characteristics
Methods	Truly randomised trial Time of randomisation: during initial surgery Double‐blind: videoed and blinded reviewer scored adhesions Power calculation: no ITT: no Location: multi‐centre (4)—Europe Timing and duration: not stated
Participants	Females, 18 to 46 years of age and older, undergoing laparoscopic peritoneal cavity surgery (N = 49) Surgery performed: laparoscopy and adhesiolysis Pre‐existing adhesions: not all women Number randomly assigned: 14 Timing second‐look laparoscopy: 6 to 10 weeks postoperative Blinding at second‐look laparoscopy: yes Exclusion criteria: participant had diabetes, hepatic or renal disorders, pelvic or abdominal infection, history of malignancy within 5 years of study; had received systemic corticosteroids within 30 days of surgery; pregnant; converted to open surgery; exposure to irrigation fluids other than RLS or saline solution; use of any other anti‐adhesion agents during surgery, use of topical haemostatic agents left in the body; elective or accidental enterotomy; no evidence of adnexal disease or endometriosis at first‐look laparoscopy
Interventions	Carboxymethylcellulose and polyethylene oxide‐based gel versus no treatment
Outcomes	Safety outcomes Other outcomes Adhesions at second‐look laparoscopy Change in adhesion score: numerical and categorical Shift analysis Subanalyses based on stage of endometriosis
Notes	mAFS used Scored per adnexa, not per participant; thus the results could not be included in the meta‐analysis, although appears to have used an external control Funded by FzioMed Inc
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "Randomisation schedule" was used
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not stated
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote: "The entire procedure was recorded on videotape...blinded reviews of the videotapes were performed to quantify adhesion scores"
Incomplete outcome data (attrition bias) All outcomes	Low risk	All 86 adnexae that were enrolled were analysed
Selective reporting (reporting bias)	Unclear risk	Data presented in full for all outcomes specified, however, no study protocol or trial registry identified for comparison
Other bias	Low risk	Funded in part by FzioMed Inc