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. 2020 Jul 17;2020(7):CD001298. doi: 10.1002/14651858.CD001298.pub5

Mettler 2004.

Study characteristics
Methods Truly randomised trial (computer‐generated).
Blinding: yes
Time of randomisation: not stated
Multi‐centre—Germany and France
Participants 64 women with a mean age of 34.9 years undergoing laparoscopy or laparotomy for treatment of fibroids
Exclusion criteria:
  1. women younger than 18 years of age

  2. Cannot adequately communicate in German or English

  3. Unwilling to undergo second‐look laparoscopy


Number of women randomly assigned: 64
Number of women undergoing second‐look laparoscopy: 62.5% return rate for second look
Interventions Polyethylene glycol versus no treatment
Outcomes Analysed in review
Presence or absence of adhesions at second‐look laparoscopy
Other outcomes
  1. Change in severity of adhesions at second‐look laparoscopy

Notes Adhesion scoring system used
Mean adhesion tenacity score
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "Computer‐generated randomization schema"
Allocation concealment (selection bias) Low risk Quote: "Until the completion of the surgical resection procedure, at which time a preprinted, sealed envelope was opened"
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Insufficient information to permit judgement
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk No mention is made of an independent, blinded reviewer at SLL
Incomplete outcome data (attrition bias)
All outcomes Low risk No missing outcome data
Selective reporting (reporting bias) Unclear risk Data presented in full for all outcomes specified, however, no study protocol or trial registry identified for comparison
Other bias Low risk Funded by Confluent Surgical