Pellicano 2003.

Study characteristics
Methods	Truly randomised trial (computer‐generated central randomisation) Double‐blinded (known by correspondence with study author) Power calculation: no Intention‐to‐treat analysis: yes Single‐centre—Italy
Participants	Infertile women undergoing laparoscopic myomectomy 36 women randomly assigned and analysed Inclusion criteria: History of infertility or recurrent miscarriages Lack of pedunculation of the main myoma Presence of not more than 4 myomas Absence of submucosal fibroids as screened by hysteroscopy No calcification of the main myoma Absence of abnormal cervical smear Negative urine pregnancy test Exclusion criteria: women who did not fulfil the inclusion criteria Mean age: 26.8 years Both groups demographically similar at the start of the study Number of women randomly assigned: 36 Number of women analysed after second‐look laparoscopy: 36
Interventions	Auto‐cross‐linked hyaluronic acid gel versus no treatment Time of application: at the end of the procedure Second‐look laparoscopy: 60 to 90 days after the primary procedure
Outcomes	Analysed in review Presence of adhesions at second‐look laparoscopy Other outcomes Incidence of adhesions with regards to the site of the primary myoma Pregnancy rates: no
Notes	Scoring system not used, only rate of the presence or absence of adhesions
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated random list
Allocation concealment (selection bias)	Unclear risk	No reference to allocation concealment in article
Blinding of participants and personnel (performance bias) All outcomes	Low risk	No reference to blinding in article, although study author contacted and confirmed both women and initial surgeons were blinded.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficent information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	36 women enrolled; all evaluated by second‐look laparoscopy
Selective reporting (reporting bias)	Unclear risk	Data presented in full for all outcomes specified, however, no study protocol or trial registry identified for comparison
Other bias	Low risk