Ten Broek 2012.

Study characteristics
Methods	Truly randomised trial (shuffled, sealed envelopes) Time of randomisation: intraoperatively—just before barrier application Single‐blinded—women Power calculation: yes ITT: no Location: single centre—Netherlands Timing and duration: Sep 2002 to March 2004; 1 year 7 months
Participants	Females, 18 years of age and older, undergoing laparoscopic gynaecological surgery for benign gynaecological conditions (N = 16) Number undergoing second‐look laparoscopy: 15 (1 was excluded at first‐look laparoscopy) Timing second‐look laparoscopy: 4 to 8 weeks postoperative Blinding at second‐look laparoscopy: yes Exclusion criteria: pregnancy, lactating, malignancy, endometriosis stage IV, if complete adhesiolysis not possible
Interventions	Hyaluronic acid and carboxymethylcellulose versus no treatment SepraSpray applied to all sites of surgical injury with potential for adhesion formation
Outcomes	Analysed in review Adhesions at second‐look laparoscopy Number of women with adhesion at SLL Mean adhesion score at SLL
Notes	Prematurely ended for financial and organisational reasons Supported by Confluent Surgery Inc. Adhesions scored by Local Adhesion Barrier Scoring System, based on mAFS score
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Sealed envelopes shuffled as randomisation. Unclear whether any other method of randomisation used
Allocation concealment (selection bias)	Low risk	Allocations concealed in sealed envelopes
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	women blinded; surgical team not blinded
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Initial surgeons blinded at time of initial outcome assessment; SLL surgeons blinded to treatment allocation
Incomplete outcome data (attrition bias) All outcomes	Low risk	No noted patient withdrawals
Selective reporting (reporting bias)	Unclear risk	Data presented in full for all outcomes specified, however, no study protocol or trial registry identified for comparison.
Other bias	Low risk