Grygier 2011.

Methods	Date of publication: 2011 Design: not reported Allocation: randomised Country: Poland
Participants	Diagnosis: acute STEMI for PPCI Number: 70 (adenosine 35; control 35) Age, years: adenosine (mean 65.3 ± 11), control (mean 64.5 ± 13) Sex: 63% men Inclusion: referred for PPCI within 6 hours of symptoms; culprit lesion was suitable for PCI and had presented with TIMI flow 0 to 2 Exclusion: chronic obstructive pulmonary disease or asthma; those who had received previous thrombolysis; patients presenting with TIMI flow 3 Withdrawals or losses to follow‐up: not reported
Interventions	Adenosine Dose: 2 mg to the left or 1 mg to the right coronary artery in 10 mL 0.9% NaCl × 2 times Route of administration: intracoronary Timing: during PPCI, immediately after crossing the lesion by guide wire and after the first balloon inflation Control Dose: 10 mL 0.9% NaCl × 2 times Route of administration: intracoronary Timing: during PPCI, immediately after crossing the lesion by guide wire and after the first balloon inflation
Outcomes	Death Non‐fatal MI TIMI (RR 0.38, 95% Cl 0.11 to 1.30) MBG Side effects: bradycardia, hypotension, AV block (not useable) Follow‐up: 1 month
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"the patient was included in the present study and randomized after informed consent had been given"; no further description
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding (performance bias and detection bias) All outcomes	Low risk	"Angiograms were reanalyzed as a single group by 2 observers, who had not participated in the invasive procedure and were unaware of the treatment received" "MBG was assessed by 2 observers who were unaware of the others' findings and of the clinical data" "physicians in charge of the patients on the coronary care floor were informed of the angiographic results of the primary PCI but were unaware of the study treatment administered during the procedure" "The electrocardiograms were analysed in a blinded fashion by an experienced cardiologist"
Incomplete outcome data (attrition bias) All outcomes	Low risk	No incomplete outcome data
Selective reporting (reporting bias)	Low risk	All outcomes stated in Methods are reported in Results
Other bias	Low risk	Not obvious