Wang 2008.

Methods	Date of publication: 2008 Design: not reported Allocation: randomised Country: China
Participants	Diagnosis: AMI for PPCI Number: 28 (adenosine 14; control 14) Age, years: adenosine (mean 48.6 ± 13.7); control (mean 46.2 ± 13.1) Sex: 82% men Inclusion: chest pain for at least 30 minutes; time from onset of symptoms of 12 hours before hospital admission; an ECG showing ST‐segment elevation of 0.1 mV in 2 or more leads; cardiac marker increased to twice the upper limit; not received fibrinolysis at emergency department; HR ≥ 50/min, BP ≥ 90/60 mmHg Exclusion: cardiogenic shock; Killip class ≥ 3; history of asthma; HR < 50/min, TIMI flow 3 Withdrawals or losses to follow‐up: not reported
Interventions	Adenosine Dose: 500 μg in 10 mL normal saline Route of administration: intracoronary Timing: during PPCI, after balloon inflation Control Dose: 10 mL normal saline Route of administration: intracoronary Timing: during PPCI, after balloon inflation
Outcomes	TIMI (RR 0.50, 95% Cl 0.11 to 2.30) Bradycardia Follow‐up: during hospitalisation
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomised, no further description
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No description
Incomplete outcome data (attrition bias) All outcomes	Low risk	No incomplete outcome data
Selective reporting (reporting bias)	Low risk	All outcomes stated in Methods are reported in Results
Other bias	Low risk	Not obvious